Pregadex 75 mg
Philippines • Dexa Medica
Indication
Neuropathic Pain
Pregabalin is indicated for the treatment of neuropathic pain in adults, including neuropathic pain associated with spinal cord injury.
Epilepsy
Pregabalin is indicated as adjunctive therapy in adult with partial seizures, with or without secondary generalization.
Generalized Anxiety Disorder
Pregabalin is indicated for the treatment of generalized anxiety disorder (GAD) in adults.
Fibromyalgia
Pregabalin is indicated for the management of fibromyalgia.
Composition
Pregabalin 75 mg
Package
Dosage Forms
CapsuleATC Classification
Warning
Dosage
Up to 17 Years
The safety and efficacy of pregabalin in children below the age of 12 years and in adolescents (12-17 years of age) have not been established. The use in children is not recommended.
18 to 65 Years Old
The dose range is 150 to 600 mg per day given in either two or three divided doses, pregabalin is given with or without food.
Neuropathic pain:
The recommended starting dose for pregabalin is 150 mg per day given as two or three divided doses. Based on individual patient response and tolerability, the dose may be increased to 300 mg per day after an interval of 3 to 7 days, and if needed, to a maximum dose of 600 mg per day after an additional week.
Epilepsy:
The recommended effective starting dose for pregabalin is 150 mg per day given as two or three divided doses. Based on individual patient response and tolerability, the dose may be increased to 300 mg per day after 1 week, and if needed, to a maximum dose of 600 mg per day may be achieved after an additional week.
Generalized anxiety disorder:
The dose range is 150 to 600 mg per day given as two or three divided doses. The need for treatment should be reassessed regularly. Pregabalin treatment can be started with a dose of 150 mg per day. Based on individual patient response and tolerability, the dose may be increased to 300 mg per day after 1 week. Following an additional week the dose may be increased to 450 mg per day. The maximum dose of 600 mg per day may be achieved after an additional week.
Fibromyalgia:
The usual dose range for most patients is 300 to 450 mg per day given in two divided doses. Some patients may derive additional benefit at 600 mg per day. Dosing should begin at 75 mg two times a day (150 mg/day) and may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day). If needed, in some patients, based on individual response and tolerability, the dose may be increased to maximum dosage of 600 mg/day after an additional week.
65 Years Old and Above
Elderly patients may require a dose reduction of pregabalin due to a decreased renal function.
Discontinuation of Pregabalin
In accordance with current clinical practice, if pregabalin has to be discontinued, it is recommended this should be done gradually over a minimum of 1 week independent of the indication.
Patients with Hepatic Impairment
No dose adjustment is required for patients with hepatic impairment.
Patients with Renal Impairment
Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug. As pregabalin clearance is directly proportional to creatinine clearance, dose reduction in patients with compromised renal function must be individualized according to creatinine clearance (Clcr).